Asset information for asset ID #3713752

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1 5-HT1A receptor agonists decrease blood pressure and heart rate via a central mechanism, by inducing peripheral vasodilation, and by stimulating the vagus nerve.[6] These effects are the result of activation of 5-HT1A receptors within the rostral ventrolateral medulla.[6] The sympatholytic antihypertensive drug urapidil is an α1-adrenergic receptor antagonist and α2-adrenergic receptor agonist, as well as 5-HT1A receptor agonist, and it has been demonstrated that the latter property contributes to its overall therapeutic effects.[7][8] Vasodilation of the blood vessels in the skin via central 5-HT1A activation increases heat dissipation from the organism out into the environment, causing a decrease in body temperature.[9][10]

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title views votes rating creation usage
?you won't see it til it's too late 1,226 7 (2.43)  2011-01-11 Background